Adrenocortical Carcinoma: Clinical Update
نویسندگان
چکیده
منابع مشابه
Update in adrenocortical carcinoma.
Adrenocortical carcinoma (ACC) is an orphan malignancy that has attracted increasing attention during the last decade. Here we provide an update on advances in the field since our last review published in this journal in 2006. The Wnt/β-catenin pathway and IGF-2 signaling have been confirmed as frequently altered signaling pathways in ACC, but recent data suggest that they are probably not suff...
متن کاملClinical results of the use of mitotane for adrenocortical carcinoma.
Mitotane (o,p'-DDD) acts mainly as an inhibitor of intramitochondrial pregnenolone and cortisol synthesis. Its adrenolytic effect depends on metabolic activation due to conversion to o,p'-DDA and o,p'-DDE. The drug has been used for 40 years in the treatment of adrenocortical carcinoma, mainly its regional and metastatic stage, as an adjuvant to surgical resection of the tumor. In the medical l...
متن کاملCutaneous metastasis in a patient with adrenocortical carcinoma
Adrenocortical carcinoma is an uncommon and aggressivemalignancy. Despite a high frequency of metastasis, cutaneousmetastasis of adrenocortical carcinoma is rare with only isolatedcase reports. Its diagnosis can be challenging based solely onhistopathological findings. Yet, the clinical history in combinationwith an immunohistochemical panel consisting of inhibin,vimentin, chromogranin, synapto...
متن کاملAdrenocortical Carcinoma and Synchronous Malignancies
OBJECTIVE Adrenocortical carcinoma (ACC) is an aggressive tumor that accounts for 0.02% of all reported cancers. ACC commonly arises in a sporadic manner, but may also manifest as part of a familial syndrome. Regardless of the setting, ACC rarely arises concurrent with other malignant tumors. METHODS In this report we describe a 32-year-old woman who on work-up for abnormal vaginal bleeding w...
متن کاملDeveloping treatment for adrenocortical carcinoma.
Cancer of the adrenal cortex (ACC) is a rare endocrine malignancy with limited treatment options. Patients typically present with autonomous hormonal overproduction and/or a large abdominal mass. Hormonal assays and medical imaging can be diagnostic, but urinary steroid profiling might be a more sensitive technique to assess malignancy in adrenal tumours. The stage of the disease at diagnosis i...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2006
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2005-2639